Edward Susko

Professor
Department of Mathematics and Statistics
Centre for Comparative Genomics and Evolutionary Bioinformatics
Dalhousie University

Telephone: (902) 494-8865
Fax : (902) 494-5130
Office: Chase 115
email: susko@mathstat.dal.ca
mail: Department of Mathematics and Statistics
         Dalhousie University
         Halifax, Nova Scotia
         Canada B3H 4R2

My main research interests are in computational biology and bioinformatics with a particular emphasis on statistical issues in molecular evolution. I also have interests, sometimes interlinked, in mixture models and data mining/machine learning. I have been working on issues in molecular evolution as part of a larger collaborative group. Students working on related projects would gain valuable experience in inter-disciplinary research.

Representative publications include

Susko, E. (2011). Improved Least Squares Topology Testing and Estimation. Systematic Biology. 60:668--675.

Wu, J. and Susko, E. (2011). A Test for Heterotachy Using Multiple Pairs of Sequences. Molecular Biology and Evolution. 28:1661--1673.

Susko, E. (2010). First-Order correct bootstrap support adjustments for splits that allow hypothesis testing when using maximum likelihood estimation. Molecular Biology and Evolution.27:1621--1629.

Wu, J. and Susko, E. (2010). Phylogenies can be inferred through pairwise sequence comparisons for most general time reversible models. Journal of Theoretical Biology. 263:587--589.

Wang, H., Susko, E. and Roger, A.J. (2009). PROCOV: maximum likelihood estimation of protein phylogeny under covarion models. BMC Evolutionary Biology. 9:225.

Wu, J. and Susko, E. (2009). General Heterotachy and Distance Method Adjustments. Molecular Biology and Evolution. 26:2689--2697.

Susko, E. (2009). Bootstrap Support is Not First Order Correct. Systematic Biology. 58:211--233.

Susko, E. (2008). On the Distributions of Bootstrap Support and Posterior Distributions for a Star Tree. Systematic Biology. 57:602--612.

Wu, J. Susko, E. and Roger, A.J. (2008). An Independent Heterotachy Model and Its Implications for Phylogeny and Divergence Time Estimation. Molecular Phylogenetics and Evolution. 46:801--806.

Leigh, J.W., Susko, E., Baumgartner, M. and Roger, A.J. (2008). Testing phylogenetic congruence in phylogenomic analysis. Systematic Biology. 57:104--115.

Susko, E. and Roger, A.J. (2007). On Reduced Amino Acid Alphabets for Phylogenetic Inference. Molecular Biology and Evolution. 24:2139--2150.

Spencer, M., Bryant, D. and Susko, E. (2007). Conditioned genome reconstruction: how to avoid choosing the conditioning genome. Systematic Biology. 56:25--43.

Wang, H., Spencer, M., Susko, E. and A. J. Roger (2007). Testing for Covarion-like Evolution in Protein Sequences. Molecular Biology and Evolution 24:294-305.

Susko, E. (2006). Using minimum bootstrap support for splits to construct confidence regions for trees. Evolutionary Bioinformatics Online. 2:137--151.

Inagaki, Y. Susko, E. and Roger, A.J. (2006). Recombination between elongation factor 1α genes from distantly-related archaeal lineages. Proceedings of the National Academy of Sciences. 103:4528--4533.